This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: MIC 101 Exam 4 Page 1 MIC 101 Exam 4 (09 December 2009) • Please put your Name and Student ID Number on your ScanTron. • Please fill-in Form A . • Please mark your Answers to Multiple Choice Questions on your ScanTron. • Please erase any Mistakes on your ScanTron very Carefully. Please do not ask any Questions during the Exam. Exception: If you think there is a Typo or an Error on any Question, please call me or your TA over. ___________________________________________________________________ Questions 1 through 11 concern Hepatitis. Hepatitis There are four important Viral Agents that can cause Hepatitis (G= inflammation of the liver): Hepatitis A Virus, Hepatitis B Virus, Hepatitis C Virus and Hepatitis Delta Virus. The Classic Symptoms of Hepatitis are extreme Fatigue, Anorexia, Nausea (G= ship), Jaundice (French= yellow), and dark Urine. Excess Bile Pigments are responsible for the Jaundice and dark Urine. The Manifestations of all Types of Hepatitis are clinically Indistinguishable. Hepatitis A Hepatitis A Virus (HAV) [also known as Enterovirus 72] is a Picornavirus (G= Small + RNA Virus ) that causes Hepatitis A (sometimes known as Infectious Hepatitis). Transmission is via the Fecal-Oral Route or via contaminated Shellfish. Hepatitis A is sometimes called Short Incubation Hepatitis. The average Incubation Time is a Month. Fewer than 50% of Hepatitis A Cases exhibit Classic Symptoms. Diagnosis of Hepatitis A involves a dramatic Rise in Liver-associated Alanine Aminotransferases (ALT). There are also Blood Tests specific for HAV Antigens or HAV-Specific Antibodies (IgM). Treatment is Supportive. Most Cases resolve in 4 to 6 Weeks. There is an effective Inactivated Virus Vaccine (Havrix™). Hepatitis A Virus infects approximately 1.5 Million People. 1. The Genome of Hepatitis A Virus consists of -- A. Single-Stranded Positive Sense RNA. B. Single-Stranded Negative Sense RNA. C. Double-Stranded RNA. D. Single Stranded DNA (Positive or Negative Sense). MIC 101 Exam 4 Page 2 2. A single large Precursor Polyprotein is expressed from a large Open Reading Frame (ORF) extending through most of the Hepatitis A Virus Genome. This Polyprotein undergoes Nascent Cleavages (involving HAV Protease 2A and HAV Protease 3C). Post-Translational Cleavages (involving HAV Protease 3C) and a final Maturation Cleavage result in a Total of -- A. Two (2) Structural Proteins (VPg and 3D) and several Non-Structural Proteins. B. Three (3) Structural Proteins (VP1, VP2, VP0) and several Non-Structural Proteins. C. Four (4) Structural Proteins (VP1, VP2, VP3, VP4) and several Non-Structural Proteins. D. Four (4) Structural Proteins (VPg, 2A, 3C, 3D) and several Non-Structural Proteins....
View Full Document
- Fall '09
- DNA, HBV, a. b. c., positive sense