lecture8npb107

lecture8npb107 - NPB 107 January 29, 2009 1. Hierarchical...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
NPB 107 January 29, 2009 1. Hierarchical signaling pathways 1. GPCR basics 1. GPCR potential as drug targets 1. GPCRs and G protein signaling
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Figure 15-1 Molecular Biology of the Cell (© Garland Science 2008) Hierarchical Signaling Pathways
Background image of page 2
1. Signal: ligand, first messenger (e.g., hormone, growth factor, neurotransmitter 1. Receptor: transmembrane protein on cell surface 1. Transducers: interacts with receptor (e.g., G protein) 1. Effector: target of transducer (e.g. adenylate cyclase, PIPLC, K + channel) 1. Second messenger: intracellular signal (e.g., cAMP, Ca 2+ , IP 3 ) 1. Intracellular target or receptor for second messenger (e.g., PKA, PKC, IP 3 receptor) 1. Ultimate target: enzymes, transcription factors, cytoskeleton, motor proteins, etc. e.g. , exempli gratia = for example i.e., id est = that is Typical Components of Hierarchical Signaling Pathways
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Figure 15-3b Molecular Biology of the Cell (© Garland Science 2008) A Non-Hierarchical Single-Step Signaling Pathway
Background image of page 4
Figure 15-17 Molecular Biology of the Cell (© Garland Science 2008) Characteristics of Hierarchical Signaling Pathways
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Figure 15-1 Molecular Biology of the Cell (© Garland Science 2008) Specifics of Hierarchical Signaling Pathways
Background image of page 6
Figure 15-16b Molecular Biology of the Cell (© Garland Science 2008) G Protein-Coupled Receptors (GPCRs)
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Figure 15-30 Molecular Biology of the Cell (© Garland Science 2008) GPCR Topology
Background image of page 8
Another View of GPCRs
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
β -AR
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/03/2010 for the course NPB 107 taught by Professor Staff during the Spring '08 term at UC Davis.

Page1 / 22

lecture8npb107 - NPB 107 January 29, 2009 1. Hierarchical...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online