npb lec 19

npb lec 19 - NPB 107 March 10, 2009 1. 1. 1. 1....

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NPB 107 March 10, 2009 1. Transcription factors 1. Histone modification 1. Proto-oncogenes to oncogenes 1. Novel cancer drugs targeting signaling molecules Reading (background only, way more info than you need to know) Alberts et al. Molecular Biology of the Cell 5 th edition Regulation of chromatin structure, pp. 222-228; How genetic switches work pp. 439-447. Chapter 20: Finding cancer-critical genes, pp. 1230-1249.
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Genes Expression is Variable and Regulated
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Cell Signaling Pathways Allow Cells to Alter Gene Expression in Response to Signals
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The Transcriptional Complex and Activation of Transcription
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Transcriptional Repression via the Transcription Machinery
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Fundamental Mechanisms Regulating Activity of Transcription Factors (and Many Other Proteins)
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Transcriptional Complexes Also Contain Chromatin Remodeling Proteins
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March 10, 2009 1. Transcription factors 1. Histone modification 1. Proto-oncogenes to oncogenes 1. Novel cancer drugs targeting signaling molecules Reading (background only, way more info than you need to know) Alberts et al. Molecular Biology of the Cell 5 th edition Regulation of chromatin structure, pp. 222-228; How genetic switches work pp. 439-447. Chapter 20: Finding cancer-critical genes, pp. 1230-1249.
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npb lec 19 - NPB 107 March 10, 2009 1. 1. 1. 1....

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