{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

10-402-HH Project

# 10-402-HH Project - BME 402 Hodgkin-Huxley Project Due 5 pm...

This preview shows pages 1–2. Sign up to view the full content.

BME 402, Hodgkin-Huxley Project Due 5 pm, Friday 3/12/10 Experiments on the Hodgkin-Huxley model of the AP The project builds on the voltage-clamp experiment of Homework 3. Conceptually, moving from voltage clamp to current clamp is like adding a new column to your spreadsheet for I, the current injection. This will be your input variable instead of using voltage like we did in class. Then you would replace the voltage column with a formula instead of a constant. What formula? The forward Euler update rule for voltage, gotten by writing KCL for the full circuit including a current source and solving for dV/dt (see below). In that way, the voltage will be updating at each step along with the other 3 variables n, m, and h. Use the following values: R m = 25,000 Ω cm 2 , C m = 1 μ F/cm 2 , gNabar = 120 ms/cm 2 , gKbar = 32 mS/cm 2 , E K = -90mV, E Na = +55mV, E leak = -65 mV. For simplicity you can model a cell with a 1 cm 2 membrane area. Remember that 1 sec = 1 Ω F. [A hint on units. Your numbers will come out trouble free if you use the following set of intercompatible units: mV (milli-volts), μS (micro-siemens), nA (nano-amps), ms (milli-seconds), and nF (nano-farads). All the current terms in your main voltage equation (from KCL) should then end up in nA, but you would do well to verify this.] 1. (a) Convert the excel version of the HH spreadsheet we did in class to Matlab code.

This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

### What students are saying

• As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

Kiran Temple University Fox School of Business ‘17, Course Hero Intern

• I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

Dana University of Pennsylvania ‘17, Course Hero Intern

• The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

Jill Tulane University ‘16, Course Hero Intern