AP_lecture2006

AP_lecture2006 - Membrane Potential Transduction of signals...

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Membrane Potential Transduction of signals at the cellular level Resting Membrane Potential Action Potential
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Why do we need to know about RMP and AP?
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Transduction of signals at the cellular level EPSP IPSP Initial segment AP Ca2+ influx Neurotransmitter Neurotransmitter releasing
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Somatodendritic part – passive conduction of the signal, with decrement
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Axon – the signal is carried without decrement
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Preliminary knowledge What is necessary to know beforehand
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Cell membrane Proteins peripheral integral non penetrating penetrating ( transmembrane) Phospholipid bilayer
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Na + - K + pump
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Na + - K + pump Extrude 3 Na + ions Bring in 2 K + ions Unequal distribution of ions Na + and Cl - extracelullary K + a A - intracelullary
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Ion channels in the cell membrane Resting channels - normally open Gated channels - closed when the membrane is at rest » opening is regulated by » 1. Membrane potential (voltage gated ) » 2. (chemicaly gated) » 3. Membrane potential plus ligand binding (Voltage and chemicaly gated) » 4. Membrane stretch (mechanicaly gated)
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voltage gated sodium channel
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Resting membrane potential
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is not a potential. It is a difference of two
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AP_lecture2006 - Membrane Potential Transduction of signals...

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