MCB164+S08+Lecture+1

MCB164+S08+Lecture+1 - MCB164 S08 Lecture 01; April 1, 2008...

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MCB164 S08 Lecture 01; April 1, 2008 Instructor: S. Burgess 1. Course overview 2. What is genetics? 3. Model genetic organsims a. Saccharomyces cerevisiae b. Caenorhabditis elegans c. Drosophila melanogaster See notes on Wiki on same topics Additional links on SmartSite: The versatile worm: genetic and genomic resources for Caenorhabditis elegans research Yeast as a model genetic organism Optional: Chapter 1 from Advanced Genetic Analysis by Scott Hawley and Michelle Walker (includes material for Lecture 02)
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Saccharomyces cerevisiae Caenorhabditis elegans Drosophila melanogaster Nonvertebrate genetic model systems
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Budding yeast -Saccharomyces cerevisiae Why it is a model organism •Model organism for cell biology, gene expression, DNA recombination and repair •Easy to culture and nonpathogenic (used for making bread and beer for >10,000 years) •All four meiotic products can be isolated following sporulation •~6,000 genes. 16 chromosomes, high gene density, low gene redundancy, few introns Life cycle •Can grow as haploid or diploid •Divides by budding off daughter cell from mother cell (~90 minutes) •A tetrad of 4 haploid spores is the product of meiosis http://www.bio.davidson.edu/courses/genomics/2004/Bossie/yeastimages.jpg Yeast as a genetic model organsim 2004
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Tetrad analysis mom dad Meiotic DNA replication Meiosis I and Meiosis II divisions Crossing over of non-sister chromatids of homologous chromosomes Four haploid spore products of meiosis (1n) diploid parent cell (2n) Yeast as a genetic model organism 2004
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MCB164+S08+Lecture+1 - MCB164 S08 Lecture 01; April 1, 2008...

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