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MCB164 final w03 KEY

MCB164 final w03 KEY - Name ID FINAL EXAM Question 1 2 3 4...

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Name_______________________________ MCB164 Winter 2003 Page of 10 1 ID #________________________________ FINAL EXAM March 22, 2003 Question Points Score 1 15 2 12 3 16 4 15 5 27 6 12 7 8 8 4 9 16 10 24 11 15 12 22 13 15 Total 200 A. This examination is closed book. B. There are 6 pages to the exam. Please count them before you start to make sure all are present. C. Please write your name on each page of the exam . D. Answer each question in the space provided. If additional space is required use the back of the page and indicate clearly that you continued your answer on the back. Do not attach additional pages. A. GOOD LUCK! Student authorization: I authorize the instructor to return the graded exam to me in the main office or to distribute it in the bin for me to pick up. Signature _____________________________
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Name_______________________________ MCB164 Winter 2003 Page of 10 2 Date_____________________ 1. (15 points) Mark the following statements as being either TRUE or FALSE ___T_____ Recombination between repeated elements is suppressed during meiosis ___F_____ Plants have much larger genomes than mammals because they have about 10 times as many genes. ___T_____ Barr-bodies (the inactive X chromosome) and centromeric heterochromatin are examples of facultative and constitutive heterochromatin, respectively. ____F____ Condensins must be released from chromosomes prior to anaphase in order to segregate sister chromatids. ____F____ The genomes of mouse and human are thought to be syntenic because both have large numbers of transposable elements. 2. (12 points) Barbara McClintock established that recombination involves the physical exchange of genetic material using maize. For her analysis she followed cytologically detectable regions of heterochromatin called “knobs” during meiosis using a strain that was heterozygous for such knobs. The drawing below shows a representation of the bivalent she might have seen during metaphase I. The bivalent as shown has one chiasma. A. Draw the structure of the two chromosomes immediately following the first meiotic division. B. Name the two sources of tension that stabilize the bivalent on the metaphase I plate when the centromeres of the two homologs are pulled by the spindle? 1. Chiasma (cross over) 2. sister chromatid cohesion distal to the site of crossing over
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Name_______________________________ MCB164 Winter 2003 Page of 10 3 3. (16 points) Consider the following ordered linear asci showing meiotic segregation patterns of wild type and mutant alleles of arg2 . Indicate in the table below (i) the type of segregation pattern of arg + : arg - (e.g. 2:6), (ii) whether or not crossing over occurred (or if you can tell) and (iii) if gene conversion has occurred. 1 2 3 4 + + + + + + + + arg + + arg arg + arg arg arg arg arg arg arg arg arg arg arg arg arg + arg arg arg + i. 2:6 4:4 3:5 4:4 ii. can’t tell no can’t tell yes iii. yes no yes no (or can’t tell) 4. (15 points) Dosage compensation equalizes expression of genes from the X chromosome in two sexes of the same species. Mark the following statements related to dosage compensation as TRUE or FALSE __F_____ Female identical twins share more phenotypic characteristics than male identical twins __T_____ A mother shares more expressed genes in common with her sons compared with her daughters.
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