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MCB164 MT2 S06 key

MCB164 MT2 S06 key - Name MCB164 Spring 2006 Page 1 of 7...

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Name_______________________________ MCB164 Spring 2006 Page of 7 1 ID #_________KEY___________________ SECOND MIDTERM MAY 11, 2006 Question Points Score 1 14 2 12 3 16 4 13 5 6 6 9 7 18 8 12 Total 100 This examination is closed book. There are 6 pages to the exam. Please count them before you start to make sure all are present . Please write your name on each page of the exam . Answer each question in the space provided. If additional space is required use the back of the page and indicate clearly that you continued your answer on the back. Do not attach additional pages. GOOD LUCK! Student authorization: I authorize the instructor to return the graded exam to me in the main office or to distribute it in the bin for me to pick up. Signature _____________________________ Date_____________________
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Name_______________________________ MCB164 Spring 2006 Page of 7 2 1. (14 points) Fill in the blanks of the partially composed letter below using vocabulary words covered during this part of the course. Dear Mom and Dad, First of all, thanks for the check I really appreciate it. I have been taking this really interesting course in genetics. We’ve been learning a lot about cancer, which should really help for my MCATs. Did you know that our genome is constantly undergoing damage and cells themselves repair it? The formation of DNA double-strand breaks (DSBs) is one of the most lethal forms of damage. DSBs are generally repaired by one of two processes: i) homolgous recombination or ii) nonhomologous end joining . The first is an error- free (or error-proof) process and the second is an error- prone process. Mutations in genes that encode enzymes that repair these breaks often lead to a high predisposition to cancer (or tumors, oncogenesis etc.) . Some of these diseases are heritable such as breast cancer , which is caused by mutation of the BRCA1 (or BRCA2) gene. We read about a new drug called KU0058684 that is a promising new chemotherapy agent for this disease. Love, your F1 p.s. next month can you send $74 so I can get a subscription to Nature? 2. (12 points) Answer the following statements as T (TRUE) or F (FALSE). __T_____Severe-combined immunodeficiency (SCID) can arise due to a loss-of-function mutation in Ku, which encodes an essential protein involved in V-D-J recombination.
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