MCB164 MT2 S07 KEY

MCB164 MT2 S07 KEY - Name_KEY_ MCB164 Spring 2007 Page 1 of...

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Name__________KEY_________________ MCB164 Spring 2007 Page of 7 1 SECOND MIDTERM May 10, 2007 Question Points Score 1 20 2 12 3 20 4 20 5 16 6 12 Total 100 This examination is closed book but you may use one 8x101/2 page with notes (double sided). There are 7 pages to the exam. Please count them before you start to make sure all are present . Please write your name on each page of the exam . Answer each question in the space provided. If additional space is required use the back of the page and indicate clearly that you continued your answer on the back. Do not attach additional pages. HAVE FUN and GOOD LUCK! Student authorization: I authorize the instructor to return the graded exam to me in the main office or to distribute it in the bin for me to pick up. Signature _____________________________ Date_____________________
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Name__________KEY_________________ MCB164 Spring 2007 Page of 7 2 1. (20 points) For each statement determine if it is TRUE (T) or FALSE (F) and briefly explain why. ____ F ___ A single event resulting in loss-of-heterozygosity in a Rb +/- individual is sufficient for malignant tumor formation. Cancer cell progression requires multiple mutations ___T___A proto-oncogene is inherited from one generation to the next. A proto-oncogene encodes a gene with a role in cellular function. So this gene is inherited. Conversion of a proto-oncogene to an activated oncogene occurs spontaneously in the individual that has cancer. ___F___ Oncogenes usually encode DNA repair factors Oncogenes usually are cell growth controlled genes that have been mutated to be inappropriately expressed or activated. Genes involved in DNA repair are generally tumor suppressor genes ___F___ Cancer cells from two different patients with b-cell lymphoma generally share the same VDJ genotype. There are thousands of possible VDJ rearrangements. The clonal nature of lymphoma would make it extremely unlikely that two individuals would have the same VDJ pattern in the cancer cell.
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Name__________KEY_________________ MCB164 Spring 2007 Page of 7 3 2. (12 points) The POL3 gene in yeast encodes DNA polymerase δ . The paper you read for HW2 describes the isolation of the pol3-ct mutation, a partial loss of function mutation that causes a decrease in both meiotic crossing over and in tract lengths associated with gene conversion. A.
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This note was uploaded on 04/04/2010 for the course MCB 164 taught by Professor Burgess during the Spring '08 term at UC Davis.

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MCB164 MT2 S07 KEY - Name_KEY_ MCB164 Spring 2007 Page 1 of...

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