MCB164+final+S09key

MCB164+final+S09key - Name_ ID #_ Final Exam June 10, 2009...

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Name_______________________________ MCB164 Spring 2009 Page of 10 ID #________________________________ Final Exam June 10, 2009 Question Points Score 1 20 2 8 3 16 4 24 5 14 6 12 7 18 8 22 9 30 10 18 11 18 Total 200 A. There are 10 pages to the exam. Please count them before you start to make sure all are present. B. Please write your name on each page of the exam . C. There may be more than one correct answer to a problem. Provide only one answer D. GOOD LUCK, HAVE FUN, and HAVE A GOOD SUMMER! 1
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Name_______________________________ MCB164 Spring 2009 Page of 10 1. (20 points) For the following choose the best answer that fits each statement. A. This protein links sister-chromatid arms prior to the first meiotic division a. HP-1 b. condensin c. cohesin d. Rad51 e. Xist B. This event initiates the process leading to chiasma formation during meiosis prophase I a. DNA methylation b. A single-strand gap that turns into a double-strand break following DNA replication c. Creation of a double-strand break after DNA replication d. Cleavage of DNA by Dicer e. T-loop formation C. Immediately prior to anaphase, homologous chromosomes are covalently linked to one another by what DNA containing structure? a. Double-Holliday junction b. Crossover c. D-loop d. T-loop e. Anaphase bridge D. A meiosis II nondisjunction event would create a tetrad with a live:dead spore ratio of a. 4:0 b. 3:1 c. 2:2 d. 1:3 e. 0:4 f. any of the above 2
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Name_______________________________ MCB164 Spring 2009 Page of 10 E. Shown below are genetic and physical maps of a chromosomal region from the feline Catus hatus containing three genes GREEN3, EGG1 and HAM7 . What feature of meiotic recombination can account for the lack of a 1:1 correlation between the two maps? a. Recomination initiation events are not evenly distributed along the chromosome b. There are more recombination initiating events in the GREEN3-EGG1 interval compared to the EGG1-HAM7 interval c. Noncrossover events occur more frequently compared to crossover events d. Gene conversion is often associated with exchange of flanking markers 2. (8 points) The boxes in the following diagram indicate particular loci. Use as many of the following symbols as you need (and as often as you need) to make it clear that cell #1 is a haploid and cell #2 is a heterozygous diploid. The symbols: A B C D E F G H a b c d e f g h 3 5 cM Physical map (kb) Genetic map (cM) 10 kb GREEN3 EGG1 HAM7
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Name_______________________________ MCB164 Spring 2009 Page of 10 3. (16 points) A. (8) Match each of the following histone variants to the process in which it functions: (only one answer per blank space) ___A__Macro H2A ___D__CENP-A ___C__Gamma-H2AX ___B__H2A.Z A. Involved in dosage compensation in humans B. Acts as an anti-silencer at the boundary between heterochromatin and euchromatin C. Binds to regions where a double-strand break has occurred. D. Specific to the chromosomal region that assembles the kinetochore
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MCB164+final+S09key - Name_ ID #_ Final Exam June 10, 2009...

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