MCB164+MT1+S09+KEY

MCB164+MT1+S09+KEY - Name_ MCB164 Spring 2009 Page 1 of 8...

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Name_______________________________ MCB164 Spring 2009 Page of 8 KEY FIRST MIDTERM April 21, 2009 Question Points Score 1 20 2 12 3 28 4 20 5 21 6 12 7 10 8 15 9 12 Total 150 This examination is closed book Please write your name on each page of the exam . There may be more than one correct answer for a given problem. You only need to provide one answer. HAVE FUN! 1
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Name_______________________________ MCB164 Spring 2009 Page of 8 1. (20 points) A. (12) Fill in the boxes below with the appropriate allele name (e.g. A, a; B, b; C, c; D, d ) that would illustrate the genotype of these viable cells following DNA replication. Pairs of vertical lines represent replicated chromosomes; circles represent centromeres. Use the following assumptions: 1. The haploid organism has two chromosomes (i.e. I and II) 2. All genes are essential, small case letters represent null alleles and are recessive to upper case alleles. 3. All genes are unlinked (i.e. on separate chromosomes) AA BB AA aa BB bb B. (8) On the diagrams above label one pair of sister chromatids and one pair of homologous chromosomes. In double heterozygous diploid AA are sisters; (AA) and (aa) are homologs 2. (12 points) Diagram the chromosome segregation pattern in human female meiosis leading to an egg disomic for chromosome 21. Include in your diagram each polar body and its respective ploidy. Nondisjunction in MII was ok as well 2 haploid Double heterozygous diploid 1 st polar body (no chromosome 21; diploid for all other chromosoems 2nd polar body- chromosome 21 disome; haploid for rest of genome Ovum- chromosome 21 disome; haploid for rest of genome + male genome complement (from sperm) to give a diploid trisomic for chomosome 21
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Name_______________________________ MCB164 Spring 2009 Page of 8 3. (28 points) You have identified 6 independent mutants in a F2 screen for mice with no ears ( m1-m6) . Two of the mutations you find are dominant ( m2 and m5 ) and so you do not include them in your complementation test. You perform pair-wise crosses betweens m1, m3, m4 and m6 mutants and observe the phenotype of the F1 progeny. You record data in the table below where “+” represents F1 with normal ears and “M” represents F1 progeny with no ears. WT
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This note was uploaded on 04/04/2010 for the course MCB 164 taught by Professor Burgess during the Spring '08 term at UC Davis.

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MCB164+MT1+S09+KEY - Name_ MCB164 Spring 2009 Page 1 of 8...

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