MCB164+S08+Final+KEY

MCB164+S08+Final+KEY - Name_KEY ID_KEY Final Exam June 7...

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Name____________KEY___________________ MCB164 Spring 2008 Page of 9 ID #___________KEY_____________________ Final Exam June 7, 2008 Question Points Score 1 16 2 12 3 12 4 8 5 12 6 24 7 6 8 23 9 14 10 26 11 16 12 15 13 16 Total 200 A. You may use one page of hand written notes on an 8.5 x 10 sheet of paper (two sided is ok). B. There are 9 pages to the exam. Please count them before you start. C. Please write your name on each page of the exam . D. Answer each question in the space provided. If additional space is required use the back of the page and indicate clearly that you continued your answer on the back. Do not attach additional pages. E. GOOD LUCK, HAVE FUN, and HAVE A GREAT SUMMER! Student authorization: I authorize the instructor to return the graded exam to me in the main office or to distribute it in the bin for me to pick up. Signature _____________________________ Date_____________________ 1
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Name____________KEY___________________ MCB164 Spring 2008 Page of 9 1. (16 points) A. (4) In mammals, which is the homogametic sex? XX female B. (4) What is the name of the process used to equalize gene expression between homogametic and heterogametic sexes of the same species? Dosage compensation C. (8) In Drosophila the expression of genes on the male X chromosome is increased two-fold compared with females. You carry out a genetic screen to identify flies that are defective in achieving increased X expression. You reason that a mutation that decreases X expression in males, but not females, would result in a male-lethal phenotype. You screen for such mutants. You predict that among the mutants you have isolated, some might carry loss-of- function mutations in genes encoding which of the following functions. (check all that apply) _____Cytosine methyltransferase _____Histone methylase __x___Histone acetylase _____ CENP-A 2. (12 points) A. (4) A DNA double-strand break (DSB) is the initiating lesion that promotes homologous recombination. How is this break created for meiotic recombination? (circle one) 1. A single-strand gap in DNA turns into a double-strand break following DNA replication 2. The transesterase activity of Spo11 cleaves the DNA and forms a covalent linkage with the 5’ end of the broken strand 3. Ionizing radiation 4. DNA is cleaved by Dicer B. (4) In meiosis I metaphase the two homologous chromosomes are joined by what structure? (circle one) 1. Holliday junction 2. Chiasma 3. D-loop 4. T-loop C. (4) Centromere cohesion is eliminated at meiosis Anaphase I to allow segregation of homolog pairs, while chromosome arm cohesion is lost at Anaphase II. TRUE or FALSE 2
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Name____________KEY___________________ MCB164 Spring 2008 Page of 9 3. (12 points) A. (8) Telomeres serve a protective function at the ends of chromosomes. When shortened, the ends can appear to the cell as double-strand breaks and are repaired as such. Shown below is a metaphase chromosome where sister chromatids have fused. At anaphase, this structure will form an anaphase bridge and undergo breakage. A. Draw a diagram of this chromosome being pulled by the spindle at anaphase and then again at
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This note was uploaded on 04/04/2010 for the course MCB 164 taught by Professor Burgess during the Spring '08 term at UC Davis.

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MCB164+S08+Final+KEY - Name_KEY ID_KEY Final Exam June 7...

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