MCB164+S08+ICE6+key - -allele Male Female Unaffected...

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MCB164 S08 Names of group members:______________KEY______________ May20, 2008 In class exercise #6 _____________________________ Score: __________ _____________________________ Women who are heterozygous for a loss-of-function mutation in the tumor-suppressor gene BRCA1 have a cumulative lifetime risk of 50%-80% chance of developing breast cancer. Below is a possible pedigree demonstrating the pattern of autosomal inheritance of the BRCA
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Unformatted text preview: -allele. Male Female: Unaffected Affected Deceased A. What is the likely BCRA1 genotype of the following individuals? Use (+) for WT and (–) for the mutant allele. Remember, BRCA1-/-confers an embryonic lethal phenotype. 1. BRCA1 +/-2. BRCA1 +/-3. BRCA1 +/-4. BRCA1 +/-B. What is a likely BRCA1 genotype of an individual tumor cell? (there is more than one correct answer, but write only one. BRCA1-/-or BRCA1-1 2 3 4...
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