Howcouldyoushowthatthesemutantsareallmutatedindifferen

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ice
Problems
 
 1.
Predict
if
each
mutation
below
will
most
likely
lead
to
a
loss
of
function,
dominant
 negative,
or
gain
of
function
allele.
 
 Frameshift
mutation
in
Ras
 
 
 Nonsense
mutation
in
the
EGFR
that
eliminates
the
cytosolic
tail
of
the
receptor
 
 
 Mutation
in
the
promoter
region
of
Ras
that
creates
a
novel
transcription
factor
 binding
site
 
 
 Mutation
in
the
splice
acceptor
site
between
the
middle
two
exons
of
Ras
 
 
 Point
mutation
in
Ras
that
destroys
the
binding
site
of
Ras‐GAP
 2.
You
are
studying
recessive
mutations
in
two
unlinked
C.
elegans
genes.
One
mutation
 gives
rise
to
a
dumpy
phenotype
(Dpy)
and
the
other
causes
the
worms
to
be
 uncoordinated
(Unc).
For
all
the
questions
below
assume
that
worms
are
homozygous
for...
View Full Document

Ask a homework question - tutors are online