Leslie_genetics - You observe the following phenotypic...

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Section 103/112 Genetics Review WORKSHEET Mendel’s First Law: Mendel’s Second Law: Product Rule: Sum Rule: Tay-Sachs is a severe autosomal recessive disease caused by the malfunction of the enzyme hexosaminidase A. The defect leads to a buildup of fatty deposits in nerve cells, causing paralysis followed by an early death. [Taken from page 74-75 of Griffiths] Calculate the probability Jim and Linda’s child will have Tay-Sachs disease.
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Consider the dust rhino. In the dust rhino one horn (A) is dominant to two horns (a) and Wrinkled Knees (C) are dominant to smooth knees (c). We generate a known heterozygote from an F 1 cross. P 1 One horn, Wrinkled knees (AACC) X Two horns, Smooth knees (aacc) All F 1 cross progeny are __________ ? What are the parental gametes? The double heterozygote is crossed to the completely recessive individual with genotype aacc. Test Cross: One horn, Wrinkled knees (AaCc) X Two horns, Smooth knees (aacc) If the loci were not on the same chromosome, what progeny would you expect?
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Unformatted text preview: You observe the following phenotypic frequencies: One horn, wrinkled knees = .36 One horn, smooth knees = .12 Two horns, smooth knees = .44 Two horns, wrinkled knees =.08 Do these results suggest linkage? If so, why? What is the distance between the horn and knee alleles? The recessive alleles k ( kidney-shaped eyes, wt=round), c (cardinal colored eyes, wt=red), and e (ebony body et=gray) identify three genes on chromosome 3 of Drosophila. Two pure breeding parental strains were crossed to obtain an F1 generation. F1 females were testcrossed with kk cc ee males, and the following progeny phenotypes were obtained: k c e 3 k c + 876 k + e 67 k + + 49 + c e 44 + c + 58 + + e 899 + + + 4 TOTAL 2000 [Ch. 4, #42 in Griffiths text] What were the parental phenotypes? Determine the order of the genes and the map distance between them. Draw the chromosomes of the Parents and F1 generation. Determine if there is interference present....
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This note was uploaded on 04/05/2010 for the course MCB 104 taught by Professor Urnov during the Spring '09 term at Berkeley.

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Leslie_genetics - You observe the following phenotypic...

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