Scott_Handout1 - 2/1/2010 MCB 104; Handout #1 1. Barbara...

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2/1/2010 MCB 104; Handout #1 1. Barbara McClintock demonstrated that genes are distributed linearly on chromosomes by demonstrating that recombination between traits correlated with recombination between knobs—physical features of maize chromosomes. Why did McClintock use these knobs and not just genes with a clear marker phenotype? 2. Recombination mapping is a great way to identify the approximate location of genes. Here are the actual results of a testcross I did to ascertain the location of a mutation in a newly-discovered Drosophila gene called cp1: f - cp1 - pw - ♀ x f - cp1 - pw - f + cp1 + pw + Relevant Genotype: Number of flies : f - cp1 - pw - / f - cp1 - pw - 1743 f - cp1 - pw + / f - cp1 - pw - 12 f - cp1 + pw + / f - cp1 - pw - 132 f - cp1 + pw - / f - cp1 - pw - 0 f + cp1 + pw + / f - cp1 - pw - 1742 f + cp1 + pw - / f - cp1 - pw - 11 f + cp1 - pw - / f - cp1 - pw - 150 f + cp1 - pw + / f - cp1 - pw - 1 2A. How far apart are f and cp1? How far apart are cp1 and pw? How far apart are f and pw? How can it be proved that cp1 is in-between f and pw? Be able to convert your recombination frequency units into centimorgans and map units. 2B.
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This note was uploaded on 04/05/2010 for the course MCB 104 taught by Professor Urnov during the Spring '09 term at University of California, Berkeley.

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Scott_Handout1 - 2/1/2010 MCB 104; Handout #1 1. Barbara...

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