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Scott_Handout3 - 2/15/2010 MCB 104; Handout #3 1. The Ras...

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2/15/2010 MCB 104; Handout #3 1. The Ras pathway is the canonical Receptor Tyrosine Kinase (RTK) signaling pathway. Put the following steps of Ras signaling in order (note: we’ll very likely be talking about the Ras pathway again in the genetics section of the course): GRB2 recruits Sos, a protein with GEF activity EGFR proteins autophosphorylate tyrosine residues on their intracellular domains EGFR proteins dimerize GRB2, an adapter protein is recruited to the activated intracellular domain of EGFR Sos mediates the exchange of Ras-GDP Ras-GTP Ligand binds to extraceullar domain of EGFR (a.k.a. HER2), an RTK MEK phosphorylates MAPK, MAPK phosphorylates downstream targets Phosphorylated Raf phosphorylates MEK, which activates MEK. Ras mediates the phosphorylation of Raf, activating Raf 2. How can one molecule of ligand binding to one receptor molecule be amplified to result in a robust downstream response? Think of specific examples of amplification in
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This note was uploaded on 04/05/2010 for the course MCB 104 taught by Professor Urnov during the Spring '09 term at Berkeley.

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Scott_Handout3 - 2/15/2010 MCB 104; Handout #3 1. The Ras...

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