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Scott_Handout4 - MCB 104 Handout#4 1 What are kinetochores...

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2/22/2010 MCB 104; Handout #4 1. What are kinetochores, and where are they found? Other key terms to know: centromere, cohesin, Dam1. Stanfurd students often confuse centromeres with centrosomes. Don’t make the same mistake. 2. Which of the following pairs are genetically identical, and which are not? homologous chromosomes at the end of mitosis; sister chromatids at the end of mitosis; homologous chromosomes at the end of meiosis; sister chromatids at the end of meiosis. 3. In mitosis, cohesin is released just before anaphase begins. In meiosis, cohesin is released along the chromosome arms during anaphase I, and is released near the centromere in during anaphase II. Why would you want to release cohesins all at once during mitosis, but sequentially during meiosis? 4. Is the centrosome necessary for spindle formation (note: Berkeley’s own Rebecca Heald did an experiment in frog egg extracts that answered this question—be familiar with the experimental approach)? Key components of the spindle to know: astral microtubules, kinetochore microtubules, polar microtubules.
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