Scott_Handout8 - 3/29/2010 MCB 104; Handout #8 1A. In...

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3/29/2010 MCB 104; Handout #8 1A. In Drosophila , will mutations that prevent the functioning of the dosage compensation machinery be lethal in males, females, or both? Explain. 1B. In C. elegans , will mutations that prevent the functioning of the dosage compensation machinery be lethal in males, females, or both? Explain. 1C. In mammals, will deletion of the X inactivation center be lethal to males, females, or both? 1D. What is the Lyon hypothesis? If a human female is heterozygous for the deletion of an X-linked gene that is essential for the survival of toenail cells, what will be her profile of X chromosome inactivation in toenail cells? 2. A female fly from a true-breeding strain that has abnormal central nervous system morphology is crossed to a wild-type male. All of the F1 progeny have abnormal nervous system morphology. However, when a male from the true-breeding strain with abnormal nervous system morphology is crossed to a wild-type female, all of the F1 progeny are wild-type. You suspect the mode of inheritance is either mitochondrial or
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Scott_Handout8 - 3/29/2010 MCB 104; Handout #8 1A. In...

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