MCB 167Discussion assignment for Friday, Feb 19Direction Selectivity in Mammalian RetinaReading :Yoshida K, Watanabe D, Ishikane H, Tachibana M, Pastan I, Nakanishi S. A key role of starburst amacrinecells in originating retinal directional selectivity and optokinetic eye movement. Neuron. 2001Jun;30(3):771‐80.Reading guide.Please read the entire paper. You should already be familiar with ON‐OFF directionselective ganglion cells from lecture. If you want more background on the properties of these cells, readBarlow HB & Levick WR, J. Physiol. 178: 477‐504, 1965. An important fact guiding the experiment designis that all retinal ganglion cells that show combined ON‐OFF responses are direction selective. Anotherimportant fact is that starburst amacrine cells receive glutamatergic input from bipolar cells, and providethe major source of GABAergic input, and the sole source of cholinergic (ACh) input, to retinal ganglion
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Barlow, starburst amacrine cells, Yoshida K, J. Physiol., Tachibana M, Watanabe D