21_Circadian Rhythms - Circadian Rhythms (and Sleep) 1....

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1 Circadian Rhythms (and Sleep) 1 1. Innate, autonomous Rhythm persists in a uniform environment with a 24hr period Rhythm maintained over a wide range of temperatures 2. Rhythm can be re-set by sensory exposure Physiological rhythms controlled by circadian clock 2
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2 Physiological rhythms controlled by circadian clock 3 Measuring circadian rhythms 4
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3 Free-running and phase-shifting clock 5 6 Variations in circadian periods
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4 How to generate a rhythm Activator Inhibitor Time delay 7 Molecular clock in Drosophila 1. CYC/CLK activate transcription of PER/TIM and VRI 2. PER/TIM/VRI accumulate in cytoplasm, at high conc move to nucleus 3. PER/TIM inhibit CYC/CLK and their own production 4. VRI inhibits CLK transcription 5. Levels of CYC/CLK fall, levels of PER/TIM/VRI fall 6. Once PER/TIM/VRI diminish, CYC/CLK become active 7. Back to step 1 8
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5 9 Principles the same, number and type of molecules varies Cell-autonomous resetting of the Drosophila clock by light 1. CRY is a cryptochrome that binds blue light
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21_Circadian Rhythms - Circadian Rhythms (and Sleep) 1....

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