22_Central Pattern Generators

22_Central Pattern Generators - Central Pattern Generators...

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1 Central Pattern Generators 1 Rhythmic motor patterns: complex, stereotyped, repetitive First systematic, scientific study of motion 1872 Gov. Leland Stanford (CA) made a bet that all four horse hooves leave the ground at the same time during gallop Hired Muybridge (photographer) to find out 2
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2 Stanford won the bet, but… 3 All rhythms require 1. 2 or more processes that sequentially increase and decrease 2. As as result, system repeatedly returns to starting state Example of rhythmic behavior: A pendulum 2 opposing processes: momentum and potential energy 4
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3 1. Cell-autonomous central pattern generator (spike-bursting) 2. Synaptic connections of network produce bursts Inhibitory connections Inhibitory plus excitatory What is the source of the rhythm? How is it produced? Types of Central Pattern Generators 5 Lobster pyloric rhythm: AB is endogonous oscillator 6
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4 How to generate cell-autonomous oscillations (Example) The cell has 1. Action potential machinery 2. Low-threshhold, non-inactivating Ca current
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This note was uploaded on 04/05/2010 for the course MCB 167 taught by Professor Feldman during the Spring '10 term at University of California, Berkeley.

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22_Central Pattern Generators - Central Pattern Generators...

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