Marfin_UW_PHEP_Talk_January_4-2010_B

Marfin_UW_PHEP_Talk_January_4-2010_B - PUBLIC HEALTH ALWAYS...

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Unformatted text preview: PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Click to edit Master subtitle style 2009 (Pandemic) H1N1 Influenza Virus January 4, 2010 UW UCONJ 445, Emergency Preparedness University of Washington, Seattle Anthony A Marfin State Epidemiologist Communicable Diseases Washington State Department of Health h u m a n ^ PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Outline Virology Influenza, the illness Seasonal vs. pandemic Current pandemic situation PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Influenza Viruses ( Orthomyxoviridae) 3 influenza virus types (sort by matrix) A, B, & C All can cause human illness Flu A Infects many mammals & birds Subtyped using surface proteins Flu B & C infects humans (no pandemics) Virus genome - 8 RNA segments (11 proteins) Frequent mutation (amino acid changes) Adaptation (sequential/cumulative mutations), e.g., 1918 influenza A H1N1 virus PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Matrix Hemagglutinin & Neuraminidase PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Gene Segment Reassortment Influenza virus co-infection of swine or human PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON What is influenza? 3 syndromes (collection of symptoms) Asymptomatic infection Develops immunity Influenza-like illness (ILI; upper respiratory tract) Surveillance: Fever + cough/sore throat Many other symptoms Severe acute respiratory illness ( SARI ) ILI + SOB, tachypnea, hypoxia Lung involvement Surveillance: Hospitalization or death PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Flu Transmission Flu Tranmission >65% of transmission in a community FROM toddlers, children, & adolescents to others Spread by respiratory droplets: Breath in droplets directly Droplets land in mouth, nose, or eyes (mucosa) Touch contaminated surfaces, then touch mucosa PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Seasonal Influenza Virus Seasonal H3N2, seasonal H1N1, & seasonal B virus Very young/old persons at risk for severe illness & death Since mid-1950s, better clinical care Antibiotics for 2 pneumonia Antivirals Supportive care & ventilator support Underutilize effective vaccine which is best & most cost- effective form of disease control PUBLIC HEALTH ALWAYS WORKING FOR A SAFER AND HEALTHIER WASHINGTON Each year, seasonal flu accounts for: 36,000 deaths 200,000 hospitalizations ~20,000,000 ILIs (may/may not seek medical care) ~30,000,000 Infections 1% PUBLIC HEALTH...
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This note was uploaded on 04/05/2010 for the course UCONJ 445 taught by Professor Beaton during the Winter '10 term at University of Washington.

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Marfin_UW_PHEP_Talk_January_4-2010_B - PUBLIC HEALTH ALWAYS...

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