Lec_9_Protozoa - Protozoan parasites Gwy-Am Shin Office:...

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Protozoan parasites Gwy-Am Shin Office: Room 2335, 4225 Roosevelt Way NE Phone: 206-543-9026 Email: gwyam@u.washington.edu
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Pathogens in the environment Viruses and prions Bacteria and rickettsiae Fungi and Algae Protozoans Helminths
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Protozoa (Introduction) Proto (=first) zoa (=animal) Unicellular (one-celled) animals > 50,000 species (mostly free-living) Protozoa vs. Humans Normally not harmful Inapparent or mild infections in normal individuals Sometimes life-threatening infections in immunosuppressed people (e.g. AIDS patients) Cryptosporidium parvum , Toxoplasma gondii , Microsporidia spp. (now fungi?), and so on
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Protozoa (structure I) Size Usually 10-50 µm smallest: 1-10 µm, largest: ~150 µm ( Balantidium coli ) Many organells Nucleus (or nuclei) Cytosome (cell mouth), food vacuoles, contractile vacuoles (osmoregulation), Golgi apparatus, mitochondria, lysosomes,… Locomotive structures: pseudopodia, flagella, cilia Cell cycle and reproduction Asexual (binary fission) and sexual (various life stages)
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Sizes of microorganisms
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Structure of prokaryotic cells
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Structure of eukaryotic cells
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Protozoa (structure II)
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Protozoa (structure III)
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Protozoa (structure III)
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Protozoa (classification I)
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Entamoeba histolytica Sarcomastigophora (Sarcodina) Cyst – 10-20 μm 4 nuclei 2 chromatoidal bars Trophozoite – 12-50 μm – 1 nucleus actively mobile Reproduction – binary fission of trophozoite – development of several (up to 4) trophozoites within the mature miltinucleated cyst.
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Life cycle of Entamoeba histolytica
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Epidemiology ( Entamoeba histolytica) Worldwide 0.5 % prevalence in developed countries 10-15 % (sometimes 50-80 %) in developing countries Most infections are inapparent (asymptomatic) Still shed large number of cysts in their feces Incubation period: 1-4 weeks Mild GI symptoms (abdominal pain, cramps, colitis and
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Lec_9_Protozoa - Protozoan parasites Gwy-Am Shin Office:...

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