Bindsandneutralizesvenom declarationshowingdecreased

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Unformatted text preview: e NAIL cDNA Methodologies had reasonable expectation of success 43 43 Highlights and Guidance s Advancements in the state of the art may render that which was once unpredictable to become predictable Regularly review the state of the art that is examined Take of note of changes in the state of the art 44 44 Example 7 s Claim An antivenom pharmaceutical composition for treating a snakebite victim, comprising Fab fragments which bind specifically to a venom of a snake of the Crotalus genus essentially free from contaminating Fc and a pharmaceutically acceptablecarrier, which neutralizes the lethality of the venom of a snake of the Crotalus genus 45 45 Example 7 s Prior Art Reference teaches whole antibodies purified from horse serum for use as an antivenom for treatment of rattlesnake bites Reference teaches producing Fab fragments from whole antibodies for use in immunoassays to detect textilotoxin 46 46 Example 7 s Evidence Declaration discussing state of the art of antivenoms which, since 1969, have only been commercially available as whole antibodies or F(ab)2 fragments Declaration stating that those in the art would not have considered Fab fragments as antivenoms because they are cleared faster than whole antibodies or F(ab)2 fragments 47 47 Example 7 s Evidence Declaration discussing success of whole antibody antivenom dependent on extra disulfide bond allowing whole antibody to bind to repeating protein antigens ­ Fab fragment does not contain such a bond bu...
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This note was uploaded on 04/05/2010 for the course LAW LAW6571 taught by Professor Abbott during the Spring '10 term at Florida State College.

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