Lecture 14 - Plasticity _3-1

Lecture 14 - Plasticity _3-1 - Neural Plasticity Cont'd -...

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Neural Plasticity Cont’d - Neurogenesis - Neurogenesis: The formation of new neurons - In developing nervous system, new neurons born from neural stem cells and migrate along “radial glia” to their appropriate location - Is there neurogenesis into adulthood? Olfactory epithelium - olfactory receptors live only about 60 days - Until recently, little support for neurogenesis in mammalian CNS - Actually discovered in 1960’s, but largely disregarded as functionally irrelevant - 80’s - 90’s, discovered in adult birds - It is now known that adult neurogenesis occurs in at least two places in mammalian CNS - Subventricular zone - rostral migratory stream - olfactory bulb - Subgranular zone of dentate gyrus in hippocampus
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Factors Affecting Adult Neurogenesis Factors increasing neurogenesis or survival of new neurons: - Environmental complexity (hippocampus) - Hippocampal-dependent (hippocampus) - Exercise (hippocampus) - Dietary restriction (hippocampus) - Antidepressants (hippocampus) - Ischemia/hypoxia (both hippocampus and olfactory system)
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This note was uploaded on 04/03/2008 for the course PSYCH 330 taught by Professor Otto during the Spring '08 term at Rutgers.

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Lecture 14 - Plasticity _3-1 - Neural Plasticity Cont'd -...

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