The numbers on the left reflect the question number on Form A, B, and C respectively
1, 25, 8
If hematopoietic stem cells were transplanted into a host and it could be shown that
descendents of the transplanted stem cells became neurons, that would be an example of
D. embryonic stem cell therapy.
E. normal hematopoiesis.
Rationale: Hematopoietic stem are adult stem cells, thus their use cannot be an example of
embryonic stem cell therapy.
HSCs are normally only differentiate into blood cell, thus if HSCs
could be shown to differentiate into a non-blood cell type, that would be an example of (highly
controversial) transdifferentiation, as discussed in Lecture 3.
2, 26, 7
Which of the following is FALSE of telomeres?
A. They are replicated by DNA polymerase.
B. They are highly repetitious sequences of DNA base pairs.
C. They are found at the ends of chromosomes.
D. They determine the life span of somatic cells.
E. They shorten as most cells age.
Telomeres are replicated by telomerase, which is a reverse transcriptase, not DNA
All the other foils are true statements about telomeres.
3, 27, 9
Embryonic stem cells differ from adult stem cells in that only embryonic stem cells
A. are 'immortal' with respect to cell division.
B. can self-renew indefinitely.
C. can produce descendents that are differentiated.
D. can be safely transplanted directly into a host.
E. are derived from cells cultured from a blastocyst
Rationale: Both embryonic and adult stem cells fulfill the definition of stem cells, and are thus
immortal with respect to cell division, which is another way of saying they can self-renew
Only adult stem cells can be safely transplants directly into a host, embryonic stem
cells produce a teratoma.
As several slides showed in both lecture 1 and lecture 3, embryonic
stem cells are typically derived from the inner cell mass of the blastocyst
4, 28, 6
Based on the assigned reading and lecture notes on apoptosis, which of the following
correctly pairs a protein molecule with its role in apoptosis?
A. Caspase--controls the permeability barrier of mitochondria
B. p53--directly degrades proteins during apoptosis
C. Fas--receptor protein that inhibits apoptosis when activated
Bcl-2--protects cells against apoptosis@
E. ICE-like proteases--involved in necrosis, not apoptosis
Rationale: Some of these foils are derived from the reading, as suggested by the question.
Lecture 1 emphasized that caspases are proteolytic enzymes, also on a review question and thus
it is Caspases, not p53, that directly degrades proteins during apoptosis.
Another name for
Caspases is ICE-like proteases, used throughout the required reading.
was also discussed