CH5 - 1 UNIT II. Cell Chapter 5 Membrane Structure and...

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Unformatted text preview: 1 UNIT II. Cell Chapter 5 Membrane Structure and Transport p. 85 3 Student Learning Outcomes: Explain the basic principles of the fluid mosaic model of biomembranes. Outline the properties of the lipid bilayers and associated proteins that compose biomembranes. Describe the factors that influence membrane fluidity. Compare and contrast the various methods of movement of ions and molecules across a semi- permeable biomembrane. Give examples of endocytosis and exocytosis in living cells. 4 Biological Membranes Basic framework of the membrane is the phospholipid bilayer Phospholipids are amphipathic molecules Hydrophobic (water-fearing) region faces in Hydrophilic (water-loving) region faces out Membranes also contain proteins and carbohydrates Relative amount of each vary Fig. 3.12, p. 49. Structure of Phospholipids 6 Biological Membranes Basic framework of the membrane is the phospholipid bilayer Phospholipids are amphipathic molecules Hydrophobic (water-fearing) region faces in Hydrophilic (water-loving) region faces out Membranes also contain proteins and carbohydrates Relative amount of each vary 7 Fluid-mosaic model (Fig. 5.1, p. 86) Membrane is considered a mosaic of lipid, protein, and carbohydrate molecules Membrane exhibits properties that resemble a fluid because lipids and proteins can move relative to each other within the membrane Fig. 5.1, p. 86. Fluid-Mosaic Model of Membrane Structure p. 86 10 Proteins bound to membranes Integral membrane proteins Lipid anchors Covalent attachment of a lipid to an amino acid side chain within a protein Transmembrane proteins One or more regions that are physically embedded in the hydrophobic region of the phospholipid bilayer Peripheral membrane proteins Noncovalently bound to regions of integral membrane proteins that project out from the membrane, or they are bound to the polar head groups of phospholipids 11 Proteins bound to membranes Integral membrane proteins Transmembrane proteins One or more regions that are physically embedded in the hydrophobic region of the phospholipid bilayer Lipid anchors Covalent attachment of a lipid to an amino acid side chain within a protein Peripheral membrane proteins Noncovalently bound to regions of integral membrane proteins that project out from the membrane, or they are bound to the polar head groups of phospholipids Fig. 5.2, p. 87 Approximately 25% of All Genes Encode Membrane Proteins (pp. 87-88) Membranes are important biologically and medically Computer programs can be used to predict the number of membrane proteins Estimated percentage of membrane proteins is substantial: 2030% of all genes may encode membrane proteins This trend is found throughout all domains of life including archaea, bacteria, and eukaryotes Approximately 25% of All Genes Encode Membrane Proteins (pp. 87-88) Membranes are important biologically and...
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This note was uploaded on 04/06/2010 for the course BIO bio 183 taught by Professor Ferzli during the Spring '08 term at N.C. State.

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CH5 - 1 UNIT II. Cell Chapter 5 Membrane Structure and...

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