lecture4 - Tertiary Structure of Nucleic Acids DNA inside...

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Tertiary Structure of Nucleic Acids DNA inside cells is highly compacted DNA of E. coli circular chromosome is 1.7mm long or 850X length of a single cell. **Length of DNA in human is approximately 2.5X the earth’s circumference. Compaction of DNA must involve highly efficient folding of duplex DNA into complex tertiary structures Length of smallest chromosome is ~ 2 cm
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Supercoiling • Involves bending or twisting of DNA axis upon itself Circular DNA or linear DNA complexed to protein can be topologically constrained and form supercoils Many organisms have circular DNA genomes --bacteria, bacteriophage, viruses * Bacteria, yeast and some organelles contain extra- chromosomal DNA elements = plasmids • One mechanism for compacting DNA Important to gene expression
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Different Forms of Supercoiled Plasmids
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copyright C. Hemenway
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Axis Axis DNA Helix (Coil) Supercoil DNA Supercoiling • Involves coiling of DNA axis • Helix Axis twists on itself
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This note was uploaded on 04/06/2010 for the course BCH BCH 453 taught by Professor Heminway during the Spring '10 term at N.C. State.

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lecture4 - Tertiary Structure of Nucleic Acids DNA inside...

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