Mar_26 - Darvon can be prepared from ethyl phenyl ketone How could ethyl phenyl ketone be synthesized O O H3C N CH3 Ph Darvon can be prepared from

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Unformatted text preview: 3/29/2010 Darvon can be prepared from ethyl phenyl ketone. How could ethyl phenyl ketone be synthesized? O O H3C N CH3 Ph Darvon can be prepared from ethyl phenyl ketone. How could ethyl phenyl ketone be prepared? O O H3C N CH3 Ph darvon CH3 Ph darvon CH3 Ph A B morphine C D Suggest a method for the preparation of racemic Darvon from ethyl phenyl ketone. O O H3C N CH3 CH3 Ph Ph D Cl Suggest Suggest a method for the preparation of racemic Darvon from ethyl phenyl ketone. O O H3C N CH3 CH3 Ph Ph 1. Ph 2. H3O Li O H3C N CH3 CH3 Ph Suggest a method for the preparation of racemic Darvon from ethyl phenyl ketone. O O H3C N CH3 CH3 Ph Ph Suggest a method for the preparation of racemic Darvon from ethyl phenyl ketone. O O H3C N CH3 CH3 Ph Ph A (CH3)2NH OH O H B C (CH3)3N OH O Ph O H3C 1. Ph Ph 2. H3O Li O H3C N CH3 CH3 Ph N CH3 CH3 1 3/29/2010 Suggest a method for the preparation of racemic Darvon from ethyl phenyl ketone. O O H3C N CH3 CH3 Ph Ph O Ph CH3 Suggest a method for performing the following transformation. O O H H O H O CH3 1. Ph 2. H3O Li O H3C N CH3 CH3 Ph O O H H O H O CH3 O O H H O H O CH3 Which of the following cations would you predict to be most reactive with H2O? Why? What are the reaction products? A H How many additional valence electrons are required for Fe to have a noble gas configuration? H N H H B A4 B 8 C 10 D 18 E 24 F 32 10 2 3/29/2010 5 ? A1 B2 C3 D4 E5 F 6 3d 4s4p 4d 5s5p 5d 6s6p Transition Transition Metals A B C D metal Fe Co Ni Cu $/oz <0.01 6.19 0.90 0.80 Transition Transition Metals A C B D metal metal Fe Co Ni Cu Ru Rh Rh Pd Pd Ag Os Ir Pt Au $/oz <0.01 6.19 0.64 0.21 400.00 2575.00 449.00 16.67 400.00 491.00 1589.00 1090.80 Which metal is the cheapest? Which metal is the most expensive? Transition Metals Valence electron count M(0) Transition Metals 3d 3d 4s4p 4d 5s5p 5d 5d 6s6p How How many valence electrons does a T.M. “need” for stability (noble gas configuration)? A8 B 10 C 14 For For a transition metal like Cobalt 3d 3d 5 orbitals 4s 1 orbital 4p 3 orbitals 9 orbitals total gives us the the “18 electron rule” D 18 E 24 F 32 Co(0) 9 electrons Co(II) 7 electrons Co(I) 8 electrons Co(III) 6 electrons But Co has only 9 electrons Where does it get the rest of the 18 electrons? Ligands! Ligands! 3 3/29/2010 Anything that bonds to a metal is called a Ligand Co(CO)4H Co(I) 8 eeCo(I) 8e8e(CO) 4 x 2e2eH2e2etotal 18e18eCΞ O 2e2edonor via lone pair Hhydride 2 eedonor Common Ligands :CΞO :PR3 :NR3 :H:CH3 :R :X-1 neutral alkenes 2e2eM 2e2e2e2e2e2e2e2e2e2e2e2e2e2e- allyl 4e4eA 0 B -1 M What is the charge on the allyl ligand? M C -2 D -3 E -4 aromatics 6e6e- M Fe(C5H5)(CO)nCH3 This is a stable 18e18eCompound. What is the oxidation state of Fe? A 0 B +1 C +2 What is the value of n? A0 B1 C2 D3 E4 II +2 -1 0 -1 Fe(C Fe(C5H5)(CO)2CH3 )(CO)n This is a stable 18e18eCompound. Compound. Fe C5H5 CH3 :C=O II -1 0 -1 D +3 E -1 =6 =6 =2 =4 = 18 What is the value of n? A0 B1 C2 D3 E4 4 ...
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This note was uploaded on 04/06/2010 for the course CHE 326 taught by Professor Fowler during the Spring '08 term at SUNY Stony Brook.

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