Lecture 10 - Immunology Danger Model Defense Systems...

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Immunology Danger Model Defense Systems Non-Specific Specific Antibody Mediated Cell Mediated Clotting 12 clotting factors +another 18+ substances -hemophilia -Factor VIII Cellular Components Red Blood Cells Erythrocytes Function: carry O2 and CO2 RBC “life cycle”: -multipotent cells of bone marrow -if O2 levels are low… -erythropoietin from Kidneys -when erythropoietin levels go up, bone marrow differentiates into RBCs -negative feedback Destroyed/Recycled: -liver -spleen -source of bilirubin
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In humans, live about 120 days Thrombocytes -in mammals, platelets -from bone marrow megakaryocytes Read and know…Platelets function in blood clotting, p. 925 Leucocytes (WBC): -immunity -also from multipotent cells (Read and Know WBC defend the body…p. 924-925)
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Danger Model -PAMPs-pathogen-associated molecular patterns -toll-like receptors -Self vs. Non-Self -Chemical Signals Figure 44-1, page 945 Major Histocompatibility Complex -glycoproteins in cell membrane Human leukocyte antigen group (HLA) Class I MHC proteins
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Lecture 10 - Immunology Danger Model Defense Systems...

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