Unformatted text preview: Biochemistry 100B WINTER 200? Bogomolni
PROBLEM SET #- 5' 1— F or the following biochemical ampliﬁcation cascade ‘ a— Identify the steps in which there is ampliﬁcation. b— calculate the overall ampliﬁcation if each ampliﬁcation step is 10 fold. e. g. how many molecules of the ﬁnal product T are produced for each molecule of
the initiation factor P. Substances A,B,C,D, and E are enzymes. The subscript a,
indicates the enzyme active form. Substances P,Q,R,S,and T are small molecules
that can act as hormones, allosteric activators or cofactors. A+P—f>A. l: B'——|e-Ba i C————~J>- C,I Q~—3—I=- R D +?’.R-F”""‘Da l E ---—-—-—-—-nu- Ba
3 ___L.. T
2— Draw a scheme of the glycogen phosphorylase cascade system as complete as you can, including all activation, ampliﬁcation, and regulation processes that take place.
(you may need a BIG piece of paper) ...
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- Winter '10