121 2009 Final

121 2009 Final - Name Last, First MCB121, Page 1 of 13...

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Name MCB121, Page 1 of 13 Last, First Gasser, Burgess MCB121 Mar. 19, 2009, Final Exam Instructions: There are thirteen pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. Amino acid Abbreviations Amino acid Abbreviations Alanine Ala A Leucine Leu L Arginine Arg R Lysine Lys K Asparagine Asn N Methionine Met M Aspartic acid Asp D Phenylalanine Phe F Cysteine Cys C Proline Pro P Glutamine Gln Q Serine Ser S Glutamic Acid Glu E Threonine Thr T Glycine Gly G Tryptophan Trp W Histidine His H Tyrosine Tyr Y Isoleucine Ile I Valine Val V Question Value Score 1 27 2 20 3 10 4 15 5 12 6 16 7 12 8 17 9 9 10 20 11 8 12 10 13 16 14 8 Total 200
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Name MCB121, Page 2 of 13 Last, First Gasser, Burgess 1. (27) One concept that appeared repeatedly in the material presented in the course this year was the process of “tethering” where one molecule held one or several other in position to facilitate an interaction, or to produce a function at a specific location. Such tethering was often essential for activating or carrying out a process. For each of the following processes describe a tethering molecule, the molecule (or molecules that it tethers), and where and how the tethering facilitates some aspect of the indicated process. The first line is filled in as an example to aid you in answering the question. Step in gene expression Tether Tethered molecule(s) Where and how it acts Change in chromatin structure Regulatory transcription factor Histone acetyl transferase (HAT) At promoter to acetylate histones and open chromatin Formation of preinitiation complex Polyadenlyation Regulated protein degradation 2. (20) For each of the following, place an “X” in the blank next to the one correct answer for each question (5 points each). a) Regulation of gene expression (from gene to active protein) happens at a variety of levels. A number of types of regulation include markers attached to lysines in particular proteins. Which of the following is NOT known to be used as a marker in some step of such regulation. Linkage of a lysine residue to a methyl group. Linkage of a lysine residue to a protein of around 8 to 9 kilodaltons. Linkage of a lysine residue to an acetyl group. Linkage of a lysine residue to a small chain of linked proteins. Linkage of a lysine residue to a cysteine through an N-S bond.
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Name MCB121, Page 3 of 13 Last, First Gasser, Burgess b) A young child is suffering from a severe recessive blood disease in which both of the child’s chromosomal copies of the gene for α -globin produce defective proteins. Which of the following methods would be most useful in effecting a permanent cure
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This note was uploaded on 04/07/2010 for the course MCB 102,103,12 taught by Professor Segel during the Spring '10 term at UC Davis.

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121 2009 Final - Name Last, First MCB121, Page 1 of 13...

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