mcb121_mt2_2007_white_key

mcb121_mt2_2007_white_key - Name MCB121, Page 1 of 8 Last,...

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Unformatted text preview: Name MCB121, Page 1 of 8 Last, First Harmer Student Authorization: I, , authorize the University to distribute publicly this graded exam ( e. g. , handed out in class, or left in a bin for me to pick up). Signature Date MCB121 May 22, 2007, Second Midterm Instructions: There are 8 pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. Regrade requests will only be considered if answers are written in pen. Question Value Score 1 12 2 14 3 18 4 36 5 12 6 12 7 14 8 32 Total 150 Name MCB121, Page 2 of 8 Last, First Harmer 1) (12) For each of the following, place an X in the blank next to the one correct answer for each question (4 points each). a) Which of the below genes is NOT transcribed by RNA Pol III? ____ tRNA ____ U1 snRNA ____ 5S rRNA ____ U6 snRNA ____ all of the above are Type III genes b) Which of the below is true of the proto-oncogene c-Myc? ____ it has modular DNA binding and transactivation domains ____ it forms a tri-molecular complex with Mad and Max ____ it normally acts to repress genes involved in cell growth ____ it binds directly to acetylated histone tails via its bromodomain ____ none of the above is true of c-Myc c) Which of the below processes is NOT coordinated by the CTD of RNA Pol II? ____ splicing of pre-mRNA ____ poly-adenylation of pre-mRNA ____ nucleosome remodeling ____ release of RNA Pol II from the promoter ____ all of the above processes are coordinated by the CTD Name MCB121, Page 3 of 8 Last, First Harmer 2) (14) True or False: (2 points each) T F The E. coli sigma factor is associated with RNA Pol throughout the process of gene transcription. T F Most nucleotide bonds occur via 5 to 3 linkages; the 5 to 5 bond found in the mRNA cap is the only exception to this rule. T F DNA footprinting can be used to determine to which region of a promoter a transcription factor binds. T F TBP binds to the minor groove of DNA in a sequence-specific manner. T F Zinc finger domains act as strong activation domains. T F Co-repressors are sequence-specific DNA binding proteins. T F Steroid hormones can regulate the intracellular localization of some transcription factors. 3) (18) The pre-initiation complex (PIC) assembles on a promoter in six steps. The protein components of the PIC are: TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA Pol II Indicate below in what order these protein complexes assemble on a promoter to form the PIC (note that you may need to use more than one factor per step). (note that you may need to use more than one factor per step)....
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mcb121_mt2_2007_white_key - Name MCB121, Page 1 of 8 Last,...

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