02082010 - . CH 3 CH 2 CH 3 CH 2 Preparation of Grignard...

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CH 310N – MWF 8:00 – Lecture 9 – M 2/8/2010 Graded Homework : HW#05 deadline = 4:00 p.m. on Tu 2/9 HW#06 deadline = 2:00 p.m. on F 2/12 Reading Assignment : No new reading Textbook Problems : 15.1-15.4, 15.7-15.11, 15.17-15.21, 15.23, 15.24 Last Time : Solving spectroscopy problems (continued…) MRI Organometallic compounds – Grignard reagents and organolithium compounds Today : Grignard reagents and organolithium compounds (continued…) Gilman reagents Due to a meeting that cannot be rescheduled, Dr. Bocknack will have office hours from 12-2p instead of from 10a-12p, on Tuesday, February 9
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Unformatted text preview: . CH 3 CH 2 CH 3 CH 2 Preparation of Grignard Reagents Grignard reagents are prepared via rxn of organohalogen compounds with Mg metal IN AN ETHEREAL SOLVENT!!! [APROTIC!!!] Br Mg ether or THF Mg CH 3 CH 2 Br ether = CH 3 CH 2 O CH 2 CH 3 THF = The mechanism involves RADICALS : Br Mg d+ d d O CH 3 CH 2 Mg Br Mg CH 3 CH 2 Br A favorable DIPOLE-DIPOLE interaction between the e rich O atom of the solvent and the e poor Mg atom causes the Grignard reagent to dissolve as it forms. Mg CH 3 CH 2 Br d+ d d O O d d...
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This note was uploaded on 04/07/2010 for the course CH 310n taught by Professor Iverson during the Spring '08 term at University of Texas at Austin.

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02082010 - . CH 3 CH 2 CH 3 CH 2 Preparation of Grignard...

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