RelativeResourceManager(13)

RelativeResourceManager(13) - Introduction to...

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Introduction to chromatographic separations Chem 420 October 20, 2008 Professor Ryan C. Bailey
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Problem Set #3 z Will be posted on Compass after class. z Due in class on October 29 z Note: This is two days later than the syllabus states. z Assignments are due at beginning of class—starts at 12 Noon! z For full credit assignments must be in box when the lecture begins. z Any assignment turned in between noon and 12:05 PM will automatically be deducted 5 points. z Assignments will NOT be accepted for credit after 12:05 PM. z Score = 0
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What is chromatography? z Separation of components from within a mixture on account of differential interactions with a medium. z Chromatography z “chroma” = color z “graphein” = writing z Comes from colored bands on column z 1952 Nobel prize in Chemistry to Martin and Synge “for their invention of partition chromatography”
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Question: z Why would anyone want to perform chromatography? z Analysis z Sample preparation z Hyphenated techniques Chromatography over the past 30 years 0 5000 10000 15000 20000 25000 20 08 2006 2004 02 2000 1998 19 96 1994 1992 90 1988 1986 84 1982 1980 78 Citations per year SciFinder search on 10/20/08 for “Chromatography” (refined to English language only)
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General description of chromatography z Sample components are dissolved in a mobile phase and forced through an immiscible stationary phase . z Strong interactions with the stationary phase will retard the speed at which components travel relative to the mobile phase . z Components within a sample that have differential interactions with the stationary phase will be spatially separated into bands or zones that reach the detector (collector) at different times.
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Types of chromatography z Column vs. planar z Gas chromatography z Liquid chromatography z Supercritical fluid chromatography
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General GC, LC, and SFC info
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Sample elution in column chromatography z Components of the sample separate from one another as they traverse the column z Notice band broadening, aka sample dilution z Chromatogram is the output of a detector that monitors the time at which components elute.
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RelativeResourceManager(13) - Introduction to...

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