week7DB.docx - Pernicious Anemia Pernicious anemia(PA is a common type of macrocytic anemia caused by a B12 deficiency(Huether McCance 2017 Macrocytic

week7DB.docx - Pernicious Anemia Pernicious anemia(PA is a...

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Pernicious Anemia Pernicious anemia (PA) is a common type of macrocytic anemia caused by a B12 deficiency (Huether & McCance, 2017). Macrocytic anemias are categorized by remarkably large stem cells called megaloblasts (Huether & McCance, 2017). The megaloblasts mature into erythrocytes in the bone marrow, which are also significant in size, thickness, and have a large volume (Huether & McCance, 2017). In PA, the underlying modification is the absence of intrinsic factor (Huether & McCance, 2017). Intrinsic factor is required for gastric absorption to process vitamin B12 (Huether & McCance, 2017). B12 is vital for the body to have nuclear maturation and DNA synthesis in the red blood cells (Huether & McCance, 2017). When a patient has a deficiency in intrinsic factor, it can be linked as a congenital or an autoimmune progression that is focused against gastric parietal cells (Huether & McCance, 2017). In most cases, autoimmune gastritis is the cause of PA (Huether & McCance, 2017). In autoimmune gastritis, gastric atrophy occurs, leading to destruction of parietal and zymogenic cells (Huether & McCance, 2017). PA patients typically have autoantibodies that fight the gastric H+ -K+ ATPase, which is an essential protein component in the parietal cell membranes (Huether & McCance, 2017). When gastric atrophy
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