Drugs - Drug Class Local Anesthetics Drug Procaine...

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Drug Class Drug Administration Receptor Mechanism Toxicity Local Anesthetics Procaine Topical (skin, airway) Injection (eye for cataract, nerve block for surgery, carpal tunnel Bier block, spinal and epidural central neural block) Within Na channels Metabolized by plasma hydrolysis Stabilizes Na channels in inactivated state – blocks AP propagation Treat overdose with benzodiazepines acting on GABAa and limiting dose. Liver metabolism via hydroxylation, conjugation, and N- dealkylation Related to plasma [] – high [] develops from: intravascular injection, overdose. drug Allergies: less rare Drug crosses placenta, BBB Increasing toxicity – tinnitus – convulsions – coma – respiratory arrest – CVS depression Airway/Breathing/Circulation/ Drugs (preventing seizure) Tetracaine
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Cocaine Esters! Amides! Lidocaine (fast in/out) Bupivicaine (slow in/out) Ropivicaine Mepivicaine General Anesthetics Inhaled N2O Use to render patient unconscious, blunt intubation response.
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