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Lecture 7 - Cell Communication Endocrine System Bio416K Spring 2010

Lecture 7 - Cell Communication Endocrine System Bio416K Spring 2010

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updated 2:19 p.m. CT, Wed., Aug. 13, 2008 Endocrine Imbalances
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Key Concepts (Themes) in Physiology 1. Mass balance 2. Homeostasis and control systems 3. Biological energy use 4. Complementarity of Structure/function 5. Communication and information flow 6. Movement of substances across membranes 7. Mass flow
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4. Long Distance Communication – Endocrine System Chapter 7, pages 216-241 /Neurohormone or Neurosecretory cell
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1. Long Distance Communication – Nervous System (Chapters 8-11) Neurotransmitter (chemical) Graded potentials and Action potentials
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1. Direct cytoplasmic transfer and 2. Contact-dependent signals 3. Local chemical communication Chapter 6, pages 179-181. Cell-to-cell Communication Communication and Information Flow - Cell-to-cell communication (by chemical and electrical signals) is essential for homeostasis
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Hormones of the Traditional Endocrine Glands Fig. 7-2, Page 218-219 of your textbook
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Hormones of the Traditional Endocrine Glands Fig. 7-2, Page 214-215 of your textbook
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Calcium Balance (Chapter 23, pages 772 – 776)
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Objectives - Endocrine System For each hormone know: (Fig. 7-2, page 218-219 of textbook) 1. Name and location of secreting gland or cell 2. Chemical class (i.e., steroid, peptide/protein, or amine) 3. Location of target cell receptor and cellular mechanism 4. Target organ(s) 5. Action(s) on targets organ(s) Major Functional Areas Under Endocrine Control: Growth and development Cell metabolism Na + and K + homeostasis Reproduction Milk production and ejection Osmoregulation Glucose control Stress response Digestion * Calcium balance Immune function
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Simple Endocrine Reflex Control Pathway High blood sugar Beta cell of pancreas Insulin secretion Insulin target cells – store glucose Lower blood glucose
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Complex Endocrine Reflex Control Pathway Decreased blood glucose levels Hypothalamic glucose sensors Interneurons Cortisol Liver gluconeogenesis Integrating Center HPA Pathway Increased blood glucose levels Feedback Loop Response Loop
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Complex Endocrine Reflex Pathways – Involve Nervous System Negative feedback Response loop
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In your endocrinology clinic, you collected the following data from several of your patients’ plasma. Samples from each patient were taken at the same time each morning since cortisol exhibits diurnal rhythms.
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