Lecture 8 - Endocrine Pathologies Bio416K Spring 2010

Lecture 8 - Endocrine Pathologies Bio416K Spring 2010 -...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Endocrine Pathologies Three basic patterns of endocrine pathology: Hormone excess (hypersecretion) Hormone deficiency (hyposecretion) Abnormal tissue responsiveness to hormone (hyper- or hyporesponsiveness) Growth Hormone Pituitary dwarfism Pituitary gigantism Acromegaly Hyperprolactinemia Thyroid Hormone Graves’ disease Cretinism Adrenal cortex hormones Adrenal medulla hormones Cushing’s disease Pheochromocytoma Addison’s disease Insulin Gonadal steroid hormones Diabetes Type I Hypogonadism Diabetes Type II ADH Diabetes insipidus
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pituitary Gigantism: Growth hormone (GH) hypersecretion in children results in gigantism as the still-active epiphyseal growth plates in bones are targeted by growth hormone. Individual becomes abnormally tall but has relatively normal body proportions. Hypersecretion commonly results from anterior pituitary tumor producing excessive amounts of growth hormone. Usual treatment is surgical removal of the tumor.
Background image of page 2
Pituitary Dwarfism Growth hormone hyposecretion in children results in deficient long bone growth and short stature. Growth hormone deficiency can also be associated with deficiencies of other anterior pituitary hormones. Growth hormone replacement therapy can promote nearly normal somatic growth
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Acromegaly Hypersecretion of growth hormone in adults after epiphyseal plates have closed. Characterized by overgrowth of the bones And cartilages of the face, hands and feet, structures still responsive to growth hormone. Hypersecretion commonly results from anterior pituitary tumor producing excessive amounts of growth hormone. Usual treatment is surgical removal of the tumor.
Background image of page 4
Epiphyseal Growth Plate of Long Bones
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hormones of the Hypothalamic-Anterior Pituitary Endocrine Pathway
Background image of page 6
Human Growth Hormone – Roger and Debbie Clemons
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Prolactin (PRL) hypersecretion results in abnormal lactation, lack of menses and infertility in females; breast enlargement, infertility and impotence in males Hypersecretion commonly results from anterior pituitary tumor cells producing excessive amounts of prolactin, most frequent abnormality of anterior pituitary tumors. Usual treatment is surgical removal of the tumor
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 24

Lecture 8 - Endocrine Pathologies Bio416K Spring 2010 -...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online