Lecture 11 - Chemical Signals and Neurotransmitters Bio416K Spring 2010

Lecture 11 - Chemical Signals and Neurotransmitters Bio416K Spring 2010

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Nervous System Uses a Variety of Chemical Signals Seven structural classes of neurocrines 1. acetylcholine 2. amines (DA, E, NE, 5-HT) 3. lipids (eicosanoids) 4. amino acids (glutamate, GABA, glycine) 5. gases (NO, CO) 6. purines (adenosine, AMP, ATP) 7. peptides (endorphins, enkephalins, substance P) Largest variety of neurotransmitters are found in the CNS > 200 different neurocrines used in CNS 1) DA 2) NE, E 3) 5-HT (serotonin) 4) glutamate 5) GABA Two primary neurotransmitters are used within the PNS 1) acetylcholine (ACh) 2) norepinephrine (NE) + epinephrine (E) - neuromodulator
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Four Classes of Membrane Receptors Simplest receptors are chemically-gated channels Other three types must utilize membrane proteins – signal transduction ICRs GPCRs
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Fast and Slow Responses in Postsynaptic Cells
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Somatic and Autonomic Motor Control (Figure 11-11, p. 397)
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Target Response Depends on Target Receptor (Figure 6-18, p. 194)
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Events at a Synapse
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Inactivation of Neurotransmitters at the Synapse
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This note was uploaded on 04/14/2010 for the course BIO Anatomy taught by Professor Findell during the Spring '10 term at University of Texas at Austin.

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Lecture 11 - Chemical Signals and Neurotransmitters Bio416K Spring 2010

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