CH 20 - 11/30/09 Chapter 20 Cancer Peyton Rous Michael...

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11/30/09 1 Chapter 20 Cancer Peyton Rous Michael Bishop and Harold Varmus
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11/30/09 2
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11/30/09 3 Cancer is the result of genetic alteration (mutations) that allow a cell to survive and divide when it should not Heritable properties of cancer cells: 1. Proliferate independent of normal constraints Benign tumor (incapable of invasion) Malignant tumor (capable of invasion) 2. Invade and colonize areas normally reserved for other cells Malignant tumor Metastasis (secondary tumor formation) The conversion of a normal cell into a cancer cell requires multiple mutations Somatic cells accumulate mutations over a lifespan despite DNA repair mechanisms
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11/30/09 4 21_44_Tumors.jpg Cancers develop by sequential accumulation of somatic mutations that confer a competitive advantage over neighboring cells. Metastasis: cells cross cellular barriers (including connective tissue) to enter the blood stream or lymph to colonize new sites. The more widely spread, the more difficult to treat.
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11/30/09 5 Cancer cells are genetically unstable: Defects in DNA replication
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This note was uploaded on 04/09/2010 for the course BIOL 213 taught by Professor Mcknight during the Spring '07 term at Texas A&M.

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CH 20 - 11/30/09 Chapter 20 Cancer Peyton Rous Michael...

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