Lecture 9 - NPB113 Mean Circulatory Pressure, Cardiac...

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January 24, 2010 1 NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function Curves 9-1
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January 24, 2010 2 NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function Curves 9-2 Pressure Development in a Closed Circulatory System – What determines arterial, capillary and venous pressures?
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January 24, 2010 3 NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function Curves 9-3
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January 24, 2010 4 NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function 9-4 Stroke Volume & Cardiac Output Stroke Volume determined by 1. Pressure Gradient for Venous Return (Sets end diastolic volume & muscle fiber length) 2. & Contractility Pressure Grad Venous Return = CVP – ESP isovolumetric relax. Central Venous Pressure Primarily function of of Venous Capacitance . Changes in venous volume through changes total circulating blood volume, changes in arterial pressure and changes in arteriolar resistance venous pressure much less effect b/c venous capacitance so large.
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NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function 9-5 Stroke Volume & Cardiac Output (Continued) Central Venous Pressure – Venous Capacitance Primary Parameter Central Venous Pressure determined by Venous Capacitance Venous capacitance changes with sympathetic activity & local metabolism and endothelial factors (action on venules & small veins). Increases capacitance decrease venous pressure Decreases capacitance increase venous pressure January 24, 2010 5
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January 24, 2010 6 NPB113 Mean Circulatory Pressure, Cardiac Output & Vascular Function 9-6 Stroke Volume & Cardiac Output (Continued) ESP isovolumetric relaxation & Press Grad Venous Return Pressure Grad Venous Return = CVP – ESP isovolumetric relax ESP isovolumetric relaxation - determined by volume of blood remaining in ventricle at end of isovolumetric relaxation. Ventricular Volume and Pressure at end isovolumetric relaxation set by
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This note was uploaded on 04/09/2010 for the course NPB npb 113 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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Lecture 9 - NPB113 Mean Circulatory Pressure, Cardiac...

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