Lecture 4 Resp

Lecture 4 Resp - NPB113 Blood Flow to Respiratory System...

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1 February 23, 2010 NPB113 Blood Flow to Respiratory System – Matching of Ventilation & Perfusion 4-1 Pulmonary Vascular System Pulmonary Blood Pressures – 30/10 with mean of 14 mm Hg. (40/11 during exercise) 500 ml blood resides in pulmonary vascular system. LA pressure ~ 8 mm Hg. SV & CO right and left hearts approximately equal – why is pulmonary arterial pressure lower than that for systemic arterial pressure? Capillary pressure lower than that in systemic – 10 mm Hg versus 20 mm Hg. Capillary system primary site of resistance to blood flow (45 – 50% total resistance in caps.) Apex to base increase in hydrostatic pressure as a consequence of conversion of gravitation potential energy to hydrostatic energy (Blood Pressure) Blood vessels – arteries, small arteries, arterioles, venules and small and large veins very compliant – much more so than in systemic circuit. Therefore, vascular pressure and vascular resistance will be influenced by hydrostatic pressure in the blood vessels and transmural pressure for the blood vessels.
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2 February 23, 2010 NPB113 Blood Flow to Respiratory System – Matching of Ventilation & Perfusion 4-2 Pulmonary Vascular System Maximal pulmonary capillary surface area = ~ 70 - 126 M 2 . Recruitment of capillary beds and increase in diffusion capacity for O2 & CO2 into the blood with increases in pulmonary artery pressure & increases in pulmonary venous pressure. Changes in recruitment and pulmonary arterial and pulmonary venous pressures have
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This note was uploaded on 04/09/2010 for the course NPB npb 113 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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Lecture 4 Resp - NPB113 Blood Flow to Respiratory System...

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