Lecture 4 Renal

Lecture 4 Renal - NPB113 Renal 4 -1 Acid Base Balance...

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1 March 2, 2010 NPB113 Renal 4 -1 Acid Base Balance – Davenport Diagrams There is a buffer curve (line) of HCO3- and pH that can be generated between the reaction of CO2 in the Plasma (small amount) and CO2 within the RBC. This is the Blood Buffer Curve for CO2 in the Blood. While we will be drawing one blood buffer line, there is really a family of blood buffer lines depending upon the oxidative state of Hb and the quantity of Hb (RBCs) present. (oxygenated Hb is more acidic -- gives up a proton, H+ - - molecule. Dexoygenated Hb is less acidic, it will bind a proton or H+.) With changes in Pco2, the relationship between HCO3- & pH moves along the blood buffer line. pH = -log[H+] = pK + log([HCO3-]/aPco2) pH = 6.1 + log(20/1) at Pco2 of 40Torr & Po2 = 100 Torr
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2 March 2, 2010 NPB113 Renal 4 -2 Acid Base Balance – Davenport Diagrams With a respiratory acidosis or alkalosis without metabolic compensation , the relationship between HCO3- and pH moves along the blood buffer line. With a metabolic acidosis or alkalosis without respiratory compensation , move down or up the isobar of Pco2 at the onset of the acidosis or alkalosis. Four Quadrants represent 1. metabolic compensation (kidney response) to the respiratory acidosis (upper left), 2. respiratory compensation to a metabolic alkalosis (upper right), 3. respiratory compensation to a metabolic
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Lecture 4 Renal - NPB113 Renal 4 -1 Acid Base Balance...

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