Lecture 3 Resp

Lecture 3 Resp - NPB113 Respiration Dynamic Properties of...

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1 February 16, 2010 NPB113 Respiration – Dynamic Properties of Respiratory System 3-1 Dynamic Properties: Pressure – Flow Relationships Dynamic Properties: Pressure – Flow Relationships Determined by parameters that affect airway resistance . Airway Resistance determined by 1. ANS Sympathetic – acting through Beta 2 receptors relaxes bronchiolar smooth muscle dilation of airways. Parasympatheti c – acting on muscarinic receptors & a series of intracellular signaling molecules contraction of bronchiolar smooth muscle airway constriction. Changes in ANS activity have affect on airway resistance in asthma with cold temperatures and allergens acting directly on bronchiolar smooth muscle and by reflex increase in parasympathetic activity increase airway resistance. 2. Irritants acting on bronchiolar smooth muscle - direct and reflex parasympathetic activation by irritants increase airway resistance.
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2 February 16, 2010 NPB113 Respiration – Dynamic Properties of Respiratory System 3-2 Dynamic Properties: Pressure – Flow Relationships Airway Resistance Determined by (cont) 3. Turbulence - dominant affect on airway resistance and airflow into and out of the lung – greater turbulence (convergence of airways) during expiration than inspiration faster drop decrease airway diameter increase airway resistance slower rate of lung emptying. Once N R exceeds 2000, have turbulent flow. Turbulent flow faster dissipation of pressure energy lower Paw Lowers Paw decrease force for airflow out of lung (= Paw – Pbs) decrease PtrL greater airway resistance. Both produce slower flow & decrease rate of filling & emptying of the lung. 5. Inflammation or allergic reaction.
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3 February 16, 2010 NPB113 Dynamic Properties of Respiratory System 3-3 Passive Expiration – Intrapleural pressure remains negative Palveolar or aw = ER/ST + P pl
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This note was uploaded on 04/09/2010 for the course NPB npb 113 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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Lecture 3 Resp - NPB113 Respiration Dynamic Properties of...

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