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Lecture 2 Resp - NPB113 Respiration 2-1 Static Properties...

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1 February 16, 2010 NPB113 Respiration 2-1 Static Properties of Lung, Chest Wall & Respiratory System Compliance Curves for Lung, Chest Wall & Total Respiratory System Compliance ( Δ V/ Δ P) the lung decreases as volume increases. Compliance chest wall low at near 0 % VC, increases near FRC to resting position of chest wall, & then decreases from 60% VC to 100% VC. At FRC, P tr for lung and chest wall equal in magnitude and opposite direction – inward directed ER/ST forces of lung balance outward directed ER chest wall. At any volume P trrs = P trL + P trcw . At volumes above FRC, compliance of the respiratory system decreases greater transmural pressure and greater muscular effort required for an increase in volume.
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2 February 16, 2010 NPB113 Respiration 2-2 Interaction of Lung and Chest Wall Forces during Inspiration and Expiration
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3 February 16, 2010 NPB113 Respiration 2-3 Non-linear Lung Compliance & Apex (top) & Base (bottom) Regional Differences in Lung Ventilation Question: What affect will regional differences in lung ventilation would have on Apex alveolar P o2 & P co2 and Base alveolar P o2 & P co2 ?
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