Lecture 1 - NPB113 Course Information Electrophysiology...

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January 4, 2010 1 NPB113 1-1 Course Information – See Syllabus Principles in Generation of a Membrane Potential Nernst Equation & Equilibrium Potential for each Ion Generation of the Membrane Potential - Determined by Changes in Permeability of Ionic Specific Channels and the Resultant Current Flow Channel States & Ion Current Flow Changes in Membrane Voltage Referenced to the Resting Membrane Potential Conventions Used in Electrophysiology to Describe Current Flow. List of Ions, Ion Channels, and Ionic Current Flow in Generation of Cardiac Action Potentials. Phases of the Cardiac Action Potential
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January 4, 2010 2 NPB113 Electrophysiology 1-2 Course Information Generation of the Membrane Potential Requires 1. Concentration Gradient for an ion or ions across the cell membrane 2. Permeability of the membrane to an ion or ions. 3. As a consequence of #1 & #2, Current flow that produces a change in the membrane potential through movement of ions down an electrochemical gradient. 4. Since the recording of a membrane potential requires current flow (movement of ions down their electrochemical gradient), membrane pumps are required to maintain the steady-state concentration gradient.
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January 4, 2010 3 NPB113 Electrophysiology 1-3 Example of Two Conditions and Affect on the Recording of a Membrane Potential K + K + Membrane Impermeable to K Will a membrane potential be recorded? K + K + Membrane Permeable to K Will a membrane potential be recorded?
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January 4, 2010 4 NPB113 Electrophysiology 1-4 Nernst Equation and the Membrane Potential K + K + Membrane Permeable to K+ Nernst Equation predicts the membrane potential generated by a concentration gradient for each ion. Requires that the membrane is permeable to the ion. E ion = (RT)/ZF[log([ion out ]/[ion in ]) Nernst Potential predicts the membrane potential, electrical gradient, required to balance, offset, a diffusion gradient. Question
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This note was uploaded on 04/09/2010 for the course NPB npb 113 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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Lecture 1 - NPB113 Course Information Electrophysiology...

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