Lecture 1 Renal - NPB113 Renal 1-1 Overview of Renal...

Info icon This preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1 March 2, 2010 NPB113 Renal 1-1 Overview of Renal Function, Concept of Clearance, & Glomerular Filtration Review anatomy of the kidney and anatomy of cortical and juxtaglomerular nephrons using your textbook (Figures 2-1, 2-2, 2-3, 2.4, +(2-6, 2-7, & 2-8) in Koeppen and Stanton) T he Role Of The Renal System Excretory System removes products of metabolism (urea, + others), H+ ions. Conserves Essential Nutrients That Are Delivered To The Kidneys sugars - glucose, galactose amino acids Regulates Body Water And Electrolytes volume regulation through conserving or excreting Na electrolyes –Na, K, Ca, and others. Critical Role In Acid - Base Balance Within The Body Kidney is the only organ in the body which can excrete H+,andconserve buffer base and synthesize HCO3-. Returns pH and buffer base concentrations, particularly HCO3-, to normal levels. Conservation and synthesis of HCO3- Conservation of monohydrogen phosphate (HPO4--)- another blood buffer
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 March 2, 2010 NPB113 Renal 1-2 Overview of Renal Function, Concept of Clearance, &Glomerular Filtration Endocrine Function Renin – Angiotensin – AldosteroneSystem Renin macula densa cells of the JGA. Angiotensinogen Angiotensin I . AngiotensinI Angiotensin II (Angiotensin) - kidney (low rate) and in lungs (high rate). Angiotensin increases blood pressure through vasoconstriction, conserves body water through synthesis and secretion Adlosterone by ZonaGlomerulosa of the adrenal cortex of Aldosterone . Aldosterone acts on thick Ascending Loop Henle, Distal Tubules, & Collecting Ducts to increase Na reabsorption with water following. Conserves circulating plasma volume. Erythropoietin – stimulates synthesis of red blood cells by the bone marrow. Calciferol ( active Vit D) converts inactive Vit D to active Vit D. Active Vit D stimulates reabsorption of Ca and PO4 by proximal tubule cells .
Image of page 2
3 March 2, 2010 NPB113 Renal 1-3 Overview of Renal Function, Concept of Clearance, &Glomerular Filtration Kidney Performs 4 Functions On Blood And Its Electrolytes And Non-Cellular Constituents 1. Filtration - Filtration apparatus includes capillary network - glomerulus capsular head of the nephron - Bowman’s Capsule that encapsulates, cups, the glomerulus. unique arrangement of the endothelial cells of the glomerular capillaries and Bowman’s Capsule, the respective basement membranes, and other cells that restrict what is filtered and unclog the filtration apparatus and remove molecules that are not filtered – see Fig. 2-4 & p.22, Ultrastructure of the Renal Corpuscle.
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern