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Unformatted text preview: Discussion question set 8 I. The Cytoskeleton: Microfilaments 1) What are the differences between microtubules and microfilaments? Microfilaments are smaller(8nm) whereas microtubules are larger in diameter (24nm) Micofilament subunit is actin, microtubule subunit is tubulin Microfilaments utilizes ATP during polymerization while microtubules utilize GTP Actin filaments do not show dynamic stability they treadmill Microfilaments have two protofilaments G actin and F actin Rate limiting step in actin polymerization is nucleation (3 subunits) 5x more proteins used in actin Arp 2/3 can bind to preexisting filament, whereas gamma trp cant 2) This graph shows that the polymerization of microfilaments is dependent on the concentration of G-Actin. Lines A, B, and C represents 3 different polymerization rates. The black dots D, E, and F represent the critical concentration [Cc] on lines B, A, and C,...
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- Spring '08